Read More

British Dementia Research Institute

A team of scientists from the British Dementia Research Institute at University College London and KKU Lyon in Belgium have been researching for years to solve this mystery. The research, published in the medical journal Science, has now revealed that scientists have learned how the patient's brain cells die during Alzheimer's disease. In the journal, scientists said that the abnormal protein formed in the brain is related to cells called necroptosis, which die during the disease. Capable of self-destruction.

Patients Suffering from Alzheimer's

Scientists have described this discovery as “interesting” which may be beneficial in the future for the treatment of this disease. The memory of patients suffering from Alzheimer's weakens over time, and the symptoms of this disease are some of them. Forgetting new things, forgetting directions while driving, losing interest in favorite hobbies, difficulty sleeping, difficulty speaking or writing, mood or personality changes, etc. Amyloid and tau in the brains of Alzheimer's patients. Abnormal proteins are called.

Alzheimer's Diseases

However, scientists have not yet been able to understand how the accumulation of abnormal proteins called amyloid and tau in the brains of people with Alzheimer's disease is linked to the development of the disease itself. The abnormal protein amyloid begins to build up in the spaces between cells or neurons, causing inflammation in the brain, against which neurons defend themselves and begin to change their internal chemistry.

British Broadcasting Corporation

Professor Bart D. Strooper, a researcher from the UK's Dementia Research Institute, told the British Broadcasting Corporation (BBC) that this is a very important and interesting discovery. How and why neurons die in Alzheimer's disease has been the subject of much speculation for 30 to 40 years, but no one has been able to pinpoint the cause. Transplanted into the brains of genetically modified mice to produce excessive amounts of the abnormal protein amyloid.

Alzheimer's Lose Brain Cells

According to the report, people who suffer from Alzheimer's lose brain cells and begin to build up abnormal proteins called amyloid and tau, which cause the symptoms of Alzheimer's disease. Amyloid is a protein that builds up in our body and brain. But during Alzheimer's disease, these amyloid clumps together, and later they cause plaques to form in the brain which is a dangerous sign.

MEG3 Molecules

According to the scientists, once researchers understand the role of MEG3 molecules in brain cells that are destroyed by necroptosis, they will be able to stop MEG3 molecules from doing their job. Professor Bart de Strooper said the discovery could be an important breakthrough in developing new drugs to treat Alzheimer's, but the research could take years.

Effective Treatment for Alzheimer

Professor Tara Spiers-Jones, from the University of Edinburgh and president of the British Neuroscience Association, hailed the discovery as a positive development. She said it 'addresses one of the fundamental gaps in Alzheimer's research, which the results are interesting and will help us in future research. However, he stressed that a lot of steps are still needed, before knowing if it is used as an effective treatment for Alzheimer's. May or may not go.

Read More